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Figure 10 | Molecular Cancer

Figure 10

From: Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma

Figure 10

Combination therapy decreases RAD001-induced activation of AKT and ERK in EpS xenograft tumors. A) Immunohistochemical staining of p-AKT, p-ERK, and Ki-67 in Asra-EPS and VAESBJ xenograft tumors in the four groups. Scale bars: 100 μm. B) Ki-67-positivity rate of Asra-EPS and VAESBJ xenograft tumors in the four groups. Columns, mean; bars, SD. *, p < 0.05, **, p < 0.01, compared with control treatment; #, p < 0.05, compared with INC280 or RAD001 monotherapy.

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