Figure 6

INC280 delays VAESBJ xenograft tumor growth in vivo . A) Effects of INC280 on VAESBJ xenograft tumor growth. Mice bearing VAESBJ xenograft tumors were treated with 10 mg/kg INC280 (n = 5) or vehicle control (n = 5) once a day. Points, mean; bars, SD. *, p < 0.05, compared with control treatment. B) VAESBJ xenograft tumor weight in control-treated and INC280-treated mice. The average tumor weight recorded at termination of the study was 2112 ± 335 mg in the control group and 1236 ± 145 mg in the INC280 group. Columns, mean; bars, SD. *, p < 0.05, compared with control treatment. C) Effects of INC280 on c-MET phosphorylation in VAESBJ xenograft tumors. Tumors were harvested 3 hours after the last administration and then cell lysates were prepared. D) Immunohistochemical staining of Ki-67 in control-treated and INC280-treated VAESBJ xenograft tumors. Scale bars: 100 μm. E) Ki-67-positivity rate of control-treated and INC280-treated VAESBJ xenograft tumors. Columns, mean; bars, SD. *, p < 0.05, compared with control treatment.