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Figure 7 | Molecular Cancer

Figure 7

From: Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma

Figure 7

RAD001-induced activation of AKT and ERK is dependent on c-MET signaling pathway in EpS. A) Effects of RAD001 on phosphorylation of c-MET and its downstream effectors in Asra-EPS and VAESBJ cells. Cells were treated with 1 nM RAD001 for 5–360 minutes. B) Effects of RAD001 on phosphorylation of AKT and ERK in Asra-EPS and VAESBJ cells transfected with anti-c-MET siRNAs or a control siRNA. Cells transfected with siRNAs were treated with 1 nM RAD001 for 1 hour.

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