Figure 7From: Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcomaRAD001-induced activation of AKT and ERK is dependent on c-MET signaling pathway in EpS. A) Effects of RAD001 on phosphorylation of c-MET and its downstream effectors in Asra-EPS and VAESBJ cells. Cells were treated with 1 nM RAD001 for 5–360 minutes. B) Effects of RAD001 on phosphorylation of AKT and ERK in Asra-EPS and VAESBJ cells transfected with anti-c-MET siRNAs or a control siRNA. Cells transfected with siRNAs were treated with 1 nM RAD001 for 1 hour.Back to article page