Skip to main content
Figure 8 | Molecular Cancer

Figure 8

From: Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma

Figure 8

Combination of RAD001 and INC280 surprisingly inhibits EpS cell growth by blocking the mTOR and c-MET pathways in vitro . A) Combined efficacy of RAD001 and INC280 on EpS cell proliferation. Cells were treated with 10 nM INC280, 10 nM RAD001, their combination, or vehicle for 72 hours. The cell number was counted every 24 hours. Points, mean; bars, SD. *, p < 0.05, **, p < 0.01, compared with control; #, p < 0.05, compared with INC280 or RAD001 monotherapy. B) PI staining fluorescence-activated cell sorting analyses of the DNA contents of Asra-EPS and VAESBJ cells in response to the combination of RAD001 and INC280. Cells were treated with 10 nM INC280, 10 nM RAD001, their combination, or vehicle for 24 hours. C) Effects of combined treatment with RAD001 and INC280 on phosphorylation of c-MET and its downstream effectors. Cells were treated with 10 nM INC280, 10 nM RAD001, their combination, or vehicle for 1 hour.

Back to article page