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Figure 6 | Molecular Cancer

Figure 6

From: MiR-124 suppresses tumor growth and metastasis by targeting Foxq1 in nasopharyngeal carcinoma

Figure 6

The suppression of down-regulated of FOXQ1 was consistent with the suppression of the ectopic miR-124 and overexpression of FOXQ1 could rescue partially the suppression of miR-124. A, 5-8 F cells were transfected with siRNA-Foxq1 or miR-124 mimics. Effect of siRNA-Foxq1 or miR-124 on cell proliferation was measured by CCK-8 assay in 5-8 F lines. (B and C), The migrated and invasive cell numbers of NPC cells. D, The protein expression level of Foxq1 was detected after transfect with siRNA-Foxq1 or miR-124 mimics. (E and F), Effect of over-expression regulated Foxq1 in lv-miR-124/5-8 F cells on cell proliferation and tablet cloning ability were measured. (G and H), Effect of up-regulated Foxq1 in lv-miR-124/5-8 F cells on cell migration and invasion were test. (I and J), Stable expression of Foxq1 in lv-miR-124/5-8 F cells (lv-Foxq1/lv-miR-124/5-8 F) was constructed. Statistical analysis was performed using the t-tests. The data represent the mean values of three independent experiments. **, P < 0.01.

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