Figure 2From: Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axisOverexpression of Pfn1 suppresses pancreatic cancer cell proliferation. (A) Western blot analysis of Pfn1 expression in five pancreatic cancer cells from the ATCC and human pancreatic ductal epithelium (HPDE) cells. α-tubulin was used as a loading control. (B) Pfn1 expression in BxPC-3/BxPC-3-LN and SW1990/SW1990HM cells. (C-D) Effect of Pfn1 overexpression and downregulation on the proliferation of MIA PaCa-2 and SW1990 cells. (E-F) Effect of Pfn1 overexpression on the proliferation of BxPC-3-LN and SW1990HM cells. (Error bars represent mean ± SD from three independent experiments. *: p < 0.05)Back to article page