Table 1 Clinicopathological features and correlation with Pfn1 expression in pancreatic ductal adenocarcinoma
From: Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis
Characteristics | No. | Pfn1-Low Score(-/+)(n = 35) | Pfn1-High Score(++/+++)(n = 37) | P value |
|---|---|---|---|---|
Age (y) | 0.842a | |||
<60 | 30 | 15 (20.8%) | 15 (20.8%) | |
≥60 | 42 | 20 (27.8%) | 22 (30.6%) | |
Gender | 0.118a | |||
Female | 25 | 9 (12.5%) | 16 (22.2%) | |
Male | 47 | 26 (36.1%) | 21 (29.2%) | |
Tumor size (cm) | 0.568a | |||
<4.0 | 47 | 24 (33.3%) | 23 (32.0%) | |
≥4.0 | 25 | 11 (15.3%) | 14 (19.4%) | |
Tumor differentiation | 0.001a | |||
Well | 13 | 3 (4.2%) | 10 (13.9%) | |
Moderate | 43 | 18 (25.0%) | 25 (34.7%) | |
Poor | 16 | 14 (19.4%) | 2 (2.8%) | |
Lymph node status (stage) | 0.101a | |||
Negative (IIA) | 44 | 18 (25.0%) | 26 (36.1%) | |
Positive (IIB) | 28 | 17 (23.6%) | 11 (15.3%) | |
Vessel Infiltration | 0.068a | |||
Negative | 56 | 24 (33.3%) | 32 (44.4%) | |
Positive | 16 | 11 (15.3%) | 5 (7.0%) | |
Nerve Infiltration | 0.683a | |||
Negative | 17 | 9 (12.5%) | 8 (11.1%) | |
Positive | 55 | 26 (36.1%) | 29 (40.3%) | |
Median survival (in months) | 14.2 | 20.9 | 0.008b |