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Table 1 Clinicopathological features and correlation with Pfn1 expression in pancreatic ductal adenocarcinoma

From: Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis

Characteristics No. Pfn1-Low Score(-/+)(n = 35) Pfn1-High Score(++/+++)(n = 37) P value
Age (y)     0.842a
  <60 30 15 (20.8%) 15 (20.8%)  
  ≥60 42 20 (27.8%) 22 (30.6%)  
Gender     0.118a
  Female 25 9 (12.5%) 16 (22.2%)  
  Male 47 26 (36.1%) 21 (29.2%)  
Tumor size (cm)     0.568a
  <4.0 47 24 (33.3%) 23 (32.0%)  
  ≥4.0 25 11 (15.3%) 14 (19.4%)  
Tumor differentiation     0.001a
  Well 13 3 (4.2%) 10 (13.9%)  
  Moderate 43 18 (25.0%) 25 (34.7%)  
  Poor 16 14 (19.4%) 2 (2.8%)  
Lymph node status (stage)     0.101a
  Negative (IIA) 44 18 (25.0%) 26 (36.1%)  
  Positive (IIB) 28 17 (23.6%) 11 (15.3%)  
Vessel Infiltration     0.068a
  Negative 56 24 (33.3%) 32 (44.4%)  
  Positive 16 11 (15.3%) 5 (7.0%)  
Nerve Infiltration     0.683a
  Negative 17 9 (12.5%) 8 (11.1%)  
  Positive 55 26 (36.1%) 29 (40.3%)  
Median survival (in months)   14.2 20.9 0.008b
  1. aP values were derived using Pearson chi-square tests.
  2. bP values were derived using a log rank test.
  3. All statistical tests are two sided.
  4. Abbreviations: Pfn1 Profilin-1.