Identification and validation of PROM1 and CRTC2 mutations in lung cancer patients

Table 1 Clinicopathological features of the lung cancer family with PROM1 and CRTC2 mutations

Patient ID	Gender	Age (years)	Alcohol consumption	Tobacco smoking	Pack years	Medical history	Histological type	TNM (Stage)	Tumor differentiation	*PROM1* mutation		*CRTC2* mutation
										Nucleotide change	Amino acid change	Nucleotide change	Amino acid change
II4	Male	65	Frequent	Former	1095	COPD, bronchiectasis	Adenocarcinoma	T1aN0M0	Moderate	841 T > G	S281R	1135G > A	R379C
III1	Male	51	Frequent	Former	365	None	Adenocarcinoma	T1bN0M0	Poor-moderate	841 T > G	S281R	1135G > A	R379C
III4	Female	37	Never	Never		None	N/A	N/A	N/A	None	None	None	None
IV1	Male	10	Never	Never		None	N/A	N/A	N/A	None	None	None	None

ISSN: 1476-4598