Figure 6

The inverse correlation between miR-27a and RKIP expression in lung adenocarcinoma tissue samples and the clinical significance of miR-27a are shown. Relative expression levels of (A) miR-27a and (B) RKIP mRNA were detected in cisplatin-sensitive (n =13) and insensitive (n = 17) lung adenocarcinoma tissues via qRT-PCR. Abundance of miRNA and RKIP mRNA was normalized to U6 RNA and GAPDH, respectively. (C) Expression levels of miR-27a and RKIP mRNA are inversely correlated among all the tissue samples (n = 30) as indicated by two-tailed Pearson’s correlation analysis, r = −0.691; p < 0.01. (D) Kaplan-Meier survival curve indicates that patients with high miR-27a expression have shorter overall survival than those with low miR-27a expression (log-rank test, P < 0.01).