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Figure 1 | Molecular Cancer

Figure 1

From: Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma

Figure 1

Downregulation of ANGPTL4 gene in HCC. (A) Expression profile of ANGPTL4 mRNA among 26 healthy liver tissues and 110 HCC patients. (B) Summary of expression difference of ANGPTL4 mRNA between paired tumor and non-tumor liver tissues among 110 HCC patients. Lower, expression in tumor was 2-fold lower than in non-tumor; Similar, expression in tumor was neither 2-fold higher non 2-fold lower than in non-tumor; Higher, expression in tumor was 2-fold higher than in non-tumor. (C) Relative expression level ratio of ANGPTL4 mRNA in HCC cell lines to normal liver cell line. (D) Copy number variation (CNV) analysis of ANGPTL4 gene in healthy donors and HCC patients. The DNA samples for CNV analysis were randomly selected from those used for mRNA analysis. (E) Methylation analysis of ANGPTL4 promoter in HCC patients by pyrosequencing. (F) Relative expression ratio of ANGPTL4 mRNA between primary and recurred tumor tissues of HCC patients. *, P < 0.05; **, P < 0.01.

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Molecular Cancer

ISSN: 1476-4598