Figure 2
From: Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs
Knock-down of GzB in ALK+ ALCL cell lines does not affect growth rate. The growth rate of Karpas 299 (A), SUP-M2 (B), or SR (C) cells expressing the indicated GzB shRNA was compared to control shRNA-expressing cells. The results represent the average and standard deviation of 3 (SUP-M2) or 4 (Karpas 299 and SR) independent experiments. The only time point where we observed a statistically significant difference between the GzB and control shRNA-expressing cell lines was at the 48 h time point where the GzB shRNA #1-expressing SR cell line was modestly higher than the control shRNA-expressing cells (p = 0.042).