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Table 1 Quantification of GzB levels in ALK+ ALCL cell lines expressing GzB shRNA

From: Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs

Cell line

shRNA construct

Relative GzB expression (% of control shRNA)

Karpas 299

GzB shRNA #1

28.6 +/− 3.2

GzB shRNA #2

48.9 +/− 7.8

GzB shRNA #3

23.8 +/− 1.4

SR

GzB shRNA #1

18.5 +/− 2.8

SUP-M2

GzB shRNA #1

37.6 +/− 7.5

GzB shRNA #3

35.1 +/− 2.9

  1. The relative mean fluorescence intensity of GzB staining in Karpas 299, SR, or SUP-M2 cells stably expressing the indicated GzB shRNA constructs compared to cells expressing control, non-targeting shRNA is indicated. The values shown represent the average and standard deviation of 3 independent experiments.