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Table 2 Pathway mapping of TQ-phosphorylated targets by Annotation cluster3

From: Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer

Database Pathway p-Value Genes identified by peptide array
KEGG_PATHWAY T cell receptor signaling pathway 0.001971 PDK1, AKT1, RAF1, PAK1*, MAP3K7
PANTHER_PATHWAY Angiogenesis 0.008722 AKT1, TCF7L2, APC, RAF1, PAK1, CTNNB1, NOS1
KEGG_PATHWAY MAPK signaling pathway 0.041478 MAX, AKT1, RAF1, PAK1, MAP3K7
KEGG_PATHWAY Chemokine signaling pathway 0.042726 AKT1, CCR2, RAF1, PAK1
KEGG_PATHWAY Renal cell carcinoma 0.053539 AKT1, RAF1, PAK1
PANTHER_PATHWAY Ras Pathway 0.054889 AKT1, RAF1, PAK1, MAP3K7
BIOCARTA Influence of Ras and Rho proteins on G1 to S Transition 0.055681 AKT1, RAF1, PAK1
KEGG_PATHWAY ErbB signaling pathway 0.079412 AKT1, RAF1, PAK1
KEGG_PATHWAY Focal adhesion 0.091138 AKT1, RAF1, PAK1, CTNNB1
KEGG_PATHWAY Fc gamma R-mediated phagocytosis 0.093575 AKT1, RAF1, PAK1
BIOCARTA MAPKinase Signaling Pathway 0.094598 MAX, RAF1, PAK1, MAP3K7
PANTHER_PATHWAY Inflammation mediated by chemokine and cytokine signaling pathway 0.229979 AKT1, CCR2, RAF1, PAK1, MAP3K7
PANTHER_PATHWAY T cell activation 0.27141 AKT1, RAF1, PAK1
  1. *PAK1 is given in bold letters.