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Figure 2 | Molecular Cancer

Figure 2

From: Cholesterol depletion by methyl-β-cyclodextrin augments tamoxifen induced cell death by enhancing its uptake in melanoma

Figure 2

MCD enhances the susceptibility of A375 and B16F10 cells to tamoxifen by alteration in cell cycle and DNA fragmentation. A375 and B16F10 cells were treated with indicated concentration of tamoxifen along with MCD. (A and D) Display of the percentage cells in different phases of cell cycle by flow cytometry. (B and E) The treated cells were assayed by DNA fragmentation. (C and F) Whole cell lysate were subjected to Western blotting and expression level of PARP, Bcl-2 and Bax was detected. GAPDH served as a loading control. Relative folds (RF) values are expressed in arbitrary unit. Data are representative of experiments performed in triplicate.

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Molecular Cancer

ISSN: 1476-4598