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Figure 1 | Molecular Cancer

Figure 1

From: Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status

Figure 1

Effect of dovitinib and/or oxaliplatin on growth and migration of tumor cells in vitro . Combination of Dovitinib and Oxaliplatin produce synergistic effect in colon cancer cell lines: (A), Representative Panel of combination effect measured by RT-CES (B), a representative experiment plotted as histogram showing an effect of oxaliplatin and/or dovitinib in cell viability using MTS assay colon cancer cell lines. (C) Combination index calculated using Biosoft calcusyn. The values represent Mean ± SEM for at least 3 independent populations measured in triplicates. (D) Images of migration of cells 24 h after injury in the presence or absence of dovitinib and/or oxaliplatin in colon cancer cell lines. (E), Percentage of wound closure at 24 h. The graph indicates Mean ± SEM of wound closure at 24 h (n = 3). *P < 0.01. Combination of dovitinib and oxaliplatin inhibits cell proliferation and migration in colon cancer cells.

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