Figure 5From: Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation statusA working model for the synergistic effect of dovitinib and/or oxaliplatin on tumor cells. We propose that simultaneous inhibition of MAPK and PI3Kinase signaling pathways by dovitinib and DNA damage by oxaliplatin play an essential role in regulating apoptosis via induction of caspases cascade leading to a significant decrease in angiogenesis and inhibition of colon cancer cell proliferation.Back to article page