Figure 4
From: TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases
Knockdown of TopBP1 or Claspin extended survival of brain metastasized mice. (A) Schedule of treatment. Whole brain irradiation (15 Gy) was performed after 2 weeks. TopBP1 or Claspin expression was inhibited for 5 days with doxycycline in drinking water at a dose of 1 mg/kg from day 12. (B) Kaplan-Meier plot comparing survival of PC14PE6/shTopBP1 (n = 7 for control, n = 6 for sham-irradiated and combination group, and n = 8 for shTopBP1 group) (a) and PC14PE6/shClaspin (n = 10 for each group) (b) orthotopic brain metastases models with indicated treatments. (C) The table presents the survival time of the mice that were injected with TopBP1 or Claspin down-regulated tumor cells under indicated conditions.