Figure 3
DEK binding correlates with binding by RNA polymerase II and an open chromatin structure. Distribution of the 2642 ChIP-seq experiments in the Encode database based on their similarity with the result of the DEK ChIP-seq. The binding pattern of every Encode experiment was compared to the binding pattern of DEK and subsequently ordered from left to right based on their similarity, with the most similar binding pattern furthest to the left and the least similar pattern furthest to the right. (A) Each black line represents a Chip-seq experiment with RNA polymerase II, showing a strong enrichment of these binding patterns among the ones most similar to that of DEK (p < 3×10−6). (B) Each black line represents a Chip-seq experiment marking open chromatin, by synthesis of results from ChIP-seq, FAIRE-seq and DNAse hypersensitivity analysis, showing strong enrichment among the binding patterns most similar to that of DEK (p < 4×10−5).