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Figure 4 | Molecular Cancer

Figure 4

From: OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway

Figure 4

Cellular effect of miR-196 is exerted via the NME4-JNK-TIMP1-MMP1/9 molecular pathway in OECM1 cells. (A) Effects of miR-196 or NME4 plasmid transfection on MAPK, TIMP1 and MMP protein expression in OECM1 cells. Protein expression was determined by western blot analysis, and the density of each band was quantified. (B) Effect of miR-196 or NME4 plasmid transfection on p-JNK and MMP9 expression in OECM1 cells. Protein expression was determined by immunofluorescence staining and confocal microscopy. (C) A hypothetical model illustrating the miR-196-NME4-JNK-TIMP1-MMP1/9 molecular signaling pathway in oral cancer. (*p < 0.05, **p < 0.01, ***p < 0.005, t-test).

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Molecular Cancer

ISSN: 1476-4598