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Figure 7 | Molecular Cancer

Figure 7

From: SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients

Figure 7

Elevated expression of SAP-dependent Mkl1 target genes is a poor prognosis factor in breast cancer independent of histological grade. Multivariate analysis supporting the Kaplan-Maier survival analysis (shown in Figure 6) for the SRF-dependent/SAP-independent (A) and SRF-independent/SAP-dependent (B) gene sets, was performed using the GOBO bioinformatics tool. The analysis was executed for all tumors (n = 1379) and in the subgroups of LN-negative (n = 1111) and untreated tumors (n = 821) (A, B), as well as in the subgroups of ER-positive (n = 856), Grade 1 (n = 141) and Grade 2 (n = 446) tumors (B), using LN-status, ER-status, and stratified histological grade (histological grade 1 and 2 vs. 3) as covariates, DMFS as endpoint and 10-year censoring. The hazard ratio and the 95% confidence interval (CI) are plotted for each of these covariates. Specified covariates may be omitted in certain comparisons, e.g. ER-status is omitted when analyzing ER-positive tumors only, or when not all of the investigated cases have clinical follow-up or clinical information for the specified covariate.

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Molecular Cancer

ISSN: 1476-4598