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Table 1 SAP-dependent Mkl1 target genes

From: SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients

Gene Description Fold Reduction in HC11-∆SAP vs. HC11-FL cells Functions
Microarrays in 0.03% FCS qRT-PCR in 0.03% FCS qRT-PCR in 3% FCS
SRF-independent genes
Tnc Tenascin C, ECM protein 3.07*** 3.50*** 26.34*** Cell adhesion, cell migration, wound healing and tissue remodeling, cancer cell invasion and metastasis [10]
Anln Anillin, actin binding protein 3.10*** 1.93*** 1.38** Cell cycle regulation [26], cell motility and cancer progression [2628]
Nox4 NADPH oxidase 4 3.31*** 94.19** 332.70*** Cell growth, differentiation and migration [29], tumor angiogenesis [30]
Adamts16 Metallopeptidase, ECM protein 3.63*** 5.70*** 14.84** Cell growth and motility [31], role in arthritis [32] and cancer [31]
Krt5 Keratin 5, intermediate filament protein 3.73*** 2.74*** 8.02*** Protein synthesis, epithelial cell growth and differentiation [33, 34]
p15 (PAF) 2810417H13Rik, PCNA-associated factor 3.91*** 1.89*** 1.34*** DNA repair and cell cycle regulation, cell survival and proliferation, tumorigenesis [3537], hematopoiesis [38]
Ass1 Argininosuccinate synthetase 1 4.23*** 3.89** 2.72** Regulation of nitric oxide production and cell viability [39, 40]
Cd34 CD34 antigen, stem cell antigen 4.25*** 10.61*** 1.72*** Vessel development and function [41], tumor growth [42, 43]
Wisp1 WNT1 inducible signaling pathway protein 1, ECM protein 4.41*** 2.54** 4.06** Cell proliferation and survival, ECM deposition and turnover, EMT, tumorigenesis, tissue remodeling [44]
Mcm6 Minichromosome maintenance complex component 6 4.42*** 2.83*** 1.30*** Cell cycle regulation [45]
Car12 Carbonic anyhydrase 12 4.58*** 16.11*** 26.07** Cell survival under hypoxic conditions, tumor-associated cell migration and invasion [46, 47]
Htatip2 Hyaluronectin, TIP30, transcriptional regulator 5.89*** 548.59*** 245.27*** Regulation of apoptosis [48], tumor growth and metastasis [49]
Kif26b Kinesin family member 26B 6.33*** 8.36*** 61.22*** Regulation of adhesion and cell polarity in kidney development [50]
SRF-dependent genes
Lox Lysyl oxidase, ECM protein 4.61*** 4.70** 12.04*** ECM turnover, connective tissue remodeling and repair, tumor progression and metastasis [51, 52]
Mmp12 Matrix metallopeptidase 12, metalloelastase 12.01*** 23.49*** 4.90** ECM degradation in tissue remodeling [49] and tumorigenesis [53]
Mmp3 Matrix metallopeptidase 3, stromelysin-1 15.64*** 14.70*** 2.08** ECM degradation in tissue remodeling [49] and tumorigenesis [54]
  1. Abbreviations: ECM extracellular matrix protein, PCNA proliferating cell nuclear antigen, EMT epithelial-to-mesenchymal transition.
  2. ***P < 0.001, **P < 0.01, Student’s t test.