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Table 1 SAP-dependent Mkl1 target genes

From: SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients

Gene

Description

Fold Reduction in HC11-∆SAP vs. HC11-FL cells

Functions

Microarrays in 0.03% FCS

qRT-PCR in 0.03% FCS

qRT-PCR in 3% FCS

SRF-independent genes

Tnc

Tenascin C, ECM protein

3.07***

3.50***

26.34***

Cell adhesion, cell migration, wound healing and tissue remodeling, cancer cell invasion and metastasis [10]

Anln

Anillin, actin binding protein

3.10***

1.93***

1.38**

Cell cycle regulation [26], cell motility and cancer progression [26–28]

Nox4

NADPH oxidase 4

3.31***

94.19**

332.70***

Cell growth, differentiation and migration [29], tumor angiogenesis [30]

Adamts16

Metallopeptidase, ECM protein

3.63***

5.70***

14.84**

Cell growth and motility [31], role in arthritis [32] and cancer [31]

Krt5

Keratin 5, intermediate filament protein

3.73***

2.74***

8.02***

Protein synthesis, epithelial cell growth and differentiation [33, 34]

p15 (PAF)

2810417H13Rik, PCNA-associated factor

3.91***

1.89***

1.34***

DNA repair and cell cycle regulation, cell survival and proliferation, tumorigenesis [35–37], hematopoiesis [38]

Ass1

Argininosuccinate synthetase 1

4.23***

3.89**

2.72**

Regulation of nitric oxide production and cell viability [39, 40]

Cd34

CD34 antigen, stem cell antigen

4.25***

10.61***

1.72***

Vessel development and function [41], tumor growth [42, 43]

Wisp1

WNT1 inducible signaling pathway protein 1, ECM protein

4.41***

2.54**

4.06**

Cell proliferation and survival, ECM deposition and turnover, EMT, tumorigenesis, tissue remodeling [44]

Mcm6

Minichromosome maintenance complex component 6

4.42***

2.83***

1.30***

Cell cycle regulation [45]

Car12

Carbonic anyhydrase 12

4.58***

16.11***

26.07**

Cell survival under hypoxic conditions, tumor-associated cell migration and invasion [46, 47]

Htatip2

Hyaluronectin, TIP30, transcriptional regulator

5.89***

548.59***

245.27***

Regulation of apoptosis [48], tumor growth and metastasis [49]

Kif26b

Kinesin family member 26B

6.33***

8.36***

61.22***

Regulation of adhesion and cell polarity in kidney development [50]

SRF-dependent genes

Lox

Lysyl oxidase, ECM protein

4.61***

4.70**

12.04***

ECM turnover, connective tissue remodeling and repair, tumor progression and metastasis [51, 52]

Mmp12

Matrix metallopeptidase 12, metalloelastase

12.01***

23.49***

4.90**

ECM degradation in tissue remodeling [49] and tumorigenesis [53]

Mmp3

Matrix metallopeptidase 3, stromelysin-1

15.64***

14.70***

2.08**

ECM degradation in tissue remodeling [49] and tumorigenesis [54]

  1. Abbreviations: ECM extracellular matrix protein, PCNA proliferating cell nuclear antigen, EMT epithelial-to-mesenchymal transition.
  2. ***P < 0.001, **P < 0.01, Student’s t test.
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Molecular Cancer

ISSN: 1476-4598