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Figure 1 | Molecular Cancer

Figure 1

From: miR-143 and miR-145 synergistically regulate ERBB3 to suppress cell proliferation and invasion in breast cancer

Figure 1

Inverse correlation between miR-143/145 levels and ERBB3 protein levels in human breast cancer tissues. (A) Western blot analysis of ERBB3 protein levels in six pairs of breast cancer tissue (BC) and noncancerous tissue (NC) samples. Left panel: representative image; right panel: quantitative analysis. (B) Quantitative RT-PCR analysis of ERBB3 mRNA levels in six pairs of BC and NC samples. (C) Quantitative RT-PCR analysis of miR-143 and miR-145 levels in six pairs of BC and NC samples. (D) Schematic description of the hypothetical duplexes formed by the interactions between the binding sites in the ERBB3 3’-UTR (top) and miR-143/145 (bottom). The predicted free energy value of each hybrid is indicated. The seed recognition sites are denoted, and all nucleotides in these regions are highly conserved across species, including human, mouse and rat. * P < 0.05; ** P < 0.01; *** P < 0.001.

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Molecular Cancer

ISSN: 1476-4598

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