Figure 4From: Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancerETV5 recapitulates the EMT phenotype found in CTC and the metastasis potential in an EC mouse model. (A) CTC-gene expression profiling in Hec1A and Hec1A-ETV5 cell lines by RT-qPCR. The results were represented as the fold change in gene expression relative to GAPDH gene expression (2-ΔΔCt). (B) Representative luminiscence examples of athymic nude mice inoculated with Hec1A (upper panels) or Hec1A-ETV5 (lower panels) cells by intracardiac injection. Luminescence images were acquired for 1 min at ventral (left image) and dorsal (right image) positions. (C) Extent of dissemination evaluated as number of metastasis and (D) as luminescence quantification of metastasis.Back to article page