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Figure 4 | Molecular Cancer

Figure 4

From: Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer

Figure 4

ETV5 recapitulates the EMT phenotype found in CTC and the metastasis potential in an EC mouse model. (A) CTC-gene expression profiling in Hec1A and Hec1A-ETV5 cell lines by RT-qPCR. The results were represented as the fold change in gene expression relative to GAPDH gene expression (2-ΔΔCt). (B) Representative luminiscence examples of athymic nude mice inoculated with Hec1A (upper panels) or Hec1A-ETV5 (lower panels) cells by intracardiac injection. Luminescence images were acquired for 1 min at ventral (left image) and dorsal (right image) positions. (C) Extent of dissemination evaluated as number of metastasis and (D) as luminescence quantification of metastasis.

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