Down regulation of Thrombospondin2 predicts poor prognosis in patients with gastric cancer

Table 1 Association among clinicopathological variables and THBS2 expression and overall survival of gastric cancer patients

Variables	Negative	Positive	Total No.	P value^a	Overall survival OS
Variables	Negative	Positive	Total No.	P value^a	Log-Rank P^b	HR(95% CI)
	No.(%)	No.(%)
Age (y)				0.112	0.743
<61	24(38.1)	39(61.9)	63			1(reference)
≥61	35(53.0)	31(47.0)	66			1.09(0.67-1.77)
Gender				0.831	0.405
Male	47(46.5)	54(53.5)	101			1(reference)
Female	12(42.9)	16(57.1)	28			0.76(0.40-1.45)
Histological grade				0.005	0.011
Well and moderate	24(33.8)	47(66.2)	71			1(reference)
Poor and other	35(60.3)	23(39.7)	58			1.89(1.16-3.09)
Tumor location				0.419	0.204
Upper	27(40.3)	40(59.7)	67			1(reference)
Middle	15(53.6)	13(46.4)	28			1.66(0.86-3.18)
Lower	17(50.0)	17(50.0)	34			1.90(0.90-4.01)
Depth of invasion				0.271	0.001
T1-T2	9(34.6)	17(65.4)	26			1(reference)
T3-T4	50(48.5)	53(51.5)	103			11.60(2.83-47.45)
Lymph node metastasis				0.454	<0.001
Absent	17(40.5)	25(59.5)	42			1(reference)
Present	42(48.3)	45(51.7)	87			5.16(2.46-10.84)
TNM stage				0.283	<0.001
I-II	21(39.6)	32(60.4)	53			1(reference)
III-IV	38(50.0)	38(50.0)	76			7.14(3.52-14.49)

Bold value is statistically significant at P < 0.05, HR hazard ratio.
^a, P value of clinicopathological variables and THBS2 expression.
^b, P value of association between clinicopathological variables and overall survival of gastric cancer patients.

ISSN: 1476-4598