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Figure 1 | Molecular Cancer

Figure 1

From: Agonist activation of estrogen receptor beta (ERβ) sensitizes malignant pleural mesothelioma cells to cisplatin cytotoxicity

Figure 1

KB9520 mediated ERβ activation affects MPM cells proliferation. A) Bar graph shows the percentage of growth inhibition of REN cells after 24 hours treatment with different concentrations of KB9520 (range 1–100 nM) versus untreated cells. B) Bar graph shows the percentage of growth inhibition of REN cells after 24 and 72 hours treatment with different concentrations of 17β-estradiol (range 1–100 nM) versus untreated cells. C) Bar graph shows the percentage of growth inhibitory effect of 10 nM KB9520 at 24 and 48 hours in mesothelium derived cells (MET5A), mesothelioma cells with different levels of endogenous ERβ expression (REN, MMB, H2596 and MSTO-211H), ERβ silenced REN and MMB cells (REN/siRNA ERβ, MMB/siRNA ERβ) and MSTO-211H/ERβ cells, which were transiently transfected to express human ERβ. Western blots, below the bar graph, show ERβ protein expression for each cell line. Tubulin was included as a loading control. Each graph is representative of three independent experiments. Each bar represents mean ± s.d. *p ≤ 0.05.

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Molecular Cancer

ISSN: 1476-4598