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Figure 5 | Molecular Cancer

Figure 5

From: Agonist activation of estrogen receptor beta (ERβ) sensitizes malignant pleural mesothelioma cells to cisplatin cytotoxicity

Figure 5

KB9520 sensitizes REN cells to cisplatin and the standard of care chemo combination. Effect on REN cell viability after 2 hours pre-treatment with KB9520 (10nM) followed by wash-off and continued growth in normal medium supplemented with different concentrations of A) cisplatin (20–100 μM), for additional 24 hours, B) pemetrexed (5–22 μM), for additional 24 hours and C) cisplatin (100 μM) or the cisplatin (100 μM)/pemetrexed (22 μM) combination, for an additional 24 hours. Each graph is representative of three independent experiments. Each point represents mean ± s.d. *p ≤ 0.05.

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Molecular Cancer

ISSN: 1476-4598