I. BLF501 action/single DXR injection | ||||||||
---|---|---|---|---|---|---|---|---|
Mouse strain | Group | Mice/Group | DXR | BLF501 25Â ÎĽg/kg | Sacrifice 48Â h | Sacrifice 72Â h | BrdU injection | |
BALB/C | UNTR | N = 7 | - | - | - | N = 7 | + | |
DXR | N = 14 (7 + 7) | + | - | N = 7 | N = 7 | + | ||
DXR +BLF501 25 μg/kg | N = 14 (7 + 7) | + | + | N = 7 | N = 7 | + | ||
BLF501 25 μg/kg | N = 14 (7 + 7) | - | + | N = 7 | N = 7 | + | ||
Mouse strain | Group | Mice/Group | DXR | BLF501 25Â ÎĽg/kg | Sacrifice 48Â h | Sacrifice 72Â h | BrdU injection | |
C57 SGLT-1 -/- | UNTR | N = 7 | - | - | - | N = 7 | + | |
 | DXR | N = 7 | + | - | - | N = 7 | + | |
 | DXR +BLF501 25 μg/kg | N = 7 | + | + | - | N = 7 | + | |
II . BLF501 action/repeated DXR plus 5-FU injections | ||||||||
Mouse strain | Group | Mice/Group | DXR +5-FU | BLF501 0.25Â ÎĽg/kg | BLF501 2.5Â ÎĽg/kg | BLF501 25Â ÎĽg/kg | Treatment days | Sacrifice day |
BALB/C | UNTR | N = 7 | - | - |  |  | - | Day 19 |
DXR + 5FU | N = 7 | + | - |  |  | Days 1, 8 and 15 | ||
DXR + 5FU +BLF501 0.25 μg/kg | N = 7 | + | + |  |  | |||
DXR + 5FU +BLF501 2.5 μg/kg | N = 7 | + | - | + |  | |||
DXR + 5FU +BLF501 25 μg/kg | N = 7 | + | - | - | + | |||
BLF501 25 μg/kg | N = 7 | - | - | - | + | |||
III . BLF501/DXR interaction | ||||||||
Mouse strain | Group | Mice/Group | DXR | BLF501 25Â ÎĽg/kg | Treatment days | Sacrifice day | ||
SKH-1 | UNTR | N = 8 | - | - | - | Day 26 | ||
DXR | N = 8 | + | - | Days 7, 14 and 21 after cell injection | ||||
DXR +BLF501 25 μg/kg | N = 8 | + | + | |||||
 | BLF501 | N = 8 | - | + |  |