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Table 1 Summary of in vivo treatments

From: Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis

I. BLF501 action/single DXR injection

Mouse strain

Group

Mice/Group

DXR

BLF501 25 μg/kg

Sacrifice 48 h

Sacrifice 72 h

BrdU injection

BALB/C

UNTR

N = 7

-

-

-

N = 7

+

DXR

N = 14 (7 + 7)

+

-

N = 7

N = 7

+

DXR +BLF501 25 μg/kg

N = 14 (7 + 7)

+

+

N = 7

N = 7

+

BLF501 25 μg/kg

N = 14 (7 + 7)

-

+

N = 7

N = 7

+

Mouse strain

Group

Mice/Group

DXR

BLF501 25 μg/kg

Sacrifice 48 h

Sacrifice 72 h

BrdU injection

C57 SGLT-1 -/-

UNTR

N = 7

-

-

-

N = 7

+

 

DXR

N = 7

+

-

-

N = 7

+

 

DXR +BLF501 25 μg/kg

N = 7

+

+

-

N = 7

+

II . BLF501 action/repeated DXR plus 5-FU injections

Mouse strain

Group

Mice/Group

DXR +5-FU

BLF501 0.25 μg/kg

BLF501 2.5 μg/kg

BLF501 25 μg/kg

Treatment days

Sacrifice day

BALB/C

UNTR

N = 7

-

-

  

-

Day 19

DXR + 5FU

N = 7

+

-

  

Days 1, 8 and 15

DXR + 5FU +BLF501 0.25 μg/kg

N = 7

+

+

  

DXR + 5FU +BLF501 2.5 μg/kg

N = 7

+

-

+

 

DXR + 5FU +BLF501 25 μg/kg

N = 7

+

-

-

+

BLF501 25 μg/kg

N = 7

-

-

-

+

III . BLF501/DXR interaction

Mouse strain

Group

Mice/Group

DXR

BLF501 25 μg/kg

Treatment days

Sacrifice day

SKH-1

UNTR

N = 8

-

-

-

Day 26

DXR

N = 8

+

-

Days 7, 14 and 21 after cell injection

DXR +BLF501 25 μg/kg

N = 8

+

+

 

BLF501

N = 8

-

+

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