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Table 1 Summary of in vivo treatments

From: Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis

I. BLF501 action/single DXR injection
Mouse strain Group Mice/Group DXR BLF501 25 μg/kg Sacrifice 48 h Sacrifice 72 h BrdU injection
BALB/C UNTR N = 7 - - - N = 7 +
DXR N = 14 (7 + 7) + - N = 7 N = 7 +
DXR +BLF501 25 μg/kg N = 14 (7 + 7) + + N = 7 N = 7 +
BLF501 25 μg/kg N = 14 (7 + 7) - + N = 7 N = 7 +
Mouse strain Group Mice/Group DXR BLF501 25 μg/kg Sacrifice 48 h Sacrifice 72 h BrdU injection
C57 SGLT-1 -/- UNTR N = 7 - - - N = 7 +
  DXR N = 7 + - - N = 7 +
  DXR +BLF501 25 μg/kg N = 7 + + - N = 7 +
II . BLF501 action/repeated DXR plus 5-FU injections
Mouse strain Group Mice/Group DXR +5-FU BLF501 0.25 μg/kg BLF501 2.5 μg/kg BLF501 25 μg/kg Treatment days Sacrifice day
BALB/C UNTR N = 7 - -    - Day 19
DXR + 5FU N = 7 + -    Days 1, 8 and 15
DXR + 5FU +BLF501 0.25 μg/kg N = 7 + +   
DXR + 5FU +BLF501 2.5 μg/kg N = 7 + - +  
DXR + 5FU +BLF501 25 μg/kg N = 7 + - - +
BLF501 25 μg/kg N = 7 - - - +
III . BLF501/DXR interaction
Mouse strain Group Mice/Group DXR BLF501 25 μg/kg Treatment days Sacrifice day
SKH-1 UNTR N = 8 - - - Day 26
DXR N = 8 + - Days 7, 14 and 21 after cell injection
DXR +BLF501 25 μg/kg N = 8 + +
  BLF501 N = 8 - +