TY - JOUR AU - Schittek, Birgit AU - Sinnberg, Tobias PY - 2014 DA - 2014/10/11 TI - Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis JO - Molecular Cancer SP - 231 VL - 13 IS - 1 AB - Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key regulatory molecules involved in cell cycle, transcription and translation, the structure of the cytoskeleton, cell-cell adhesion and receptor-coupled signal transduction. They regulate key signaling pathways known to be critically involved in tumor progression. Recent results point to an altered expression or activity of different CK1 isoforms in tumor cells. This review summarizes the expression and biological function of CK1 family members in normal and malignant cells and the evidence obtained so far about their role in tumorigenesis. SN - 1476-4598 UR - https://doi.org/10.1186/1476-4598-13-231 DO - 10.1186/1476-4598-13-231 ID - Schittek2014 ER -