Table 1 List of differentially expressed genes following MST-312 treatment in brain tumour cells
From: Targeting DNA-PKcs and telomerase in brain tumour cells
Gene symbol | KNS60* | ONS76* |
|---|---|---|
Cell cycle proteins | Â | Â |
CCNB1 | -1.59 | 1.49 |
BIRC5 | -1.32 | 2.50 |
BIRC6 | -1.51 | -1.52 |
ANAPC4 | -1.40 | 1.11 |
DNA damage response proteins | Â | Â |
ATM | -1.58 | -1.16 |
RAD 50 | -1.85 | -1.68 |
BRCA1 | 1.02 | 1.48 |
PARP1 | 1.11 | 1.31 |
ERCC5 | 1.27 | -1.04 |
BLM | -1.59 | 1.20 |
APTX | -1.26 | -1.57 |
DAPK3 | 1.10 | 1.48 |
Telomere and Telomerase | Â | Â |
TIN2 | -1.57 | -1.16 |
TERF1 | 1.21 | -1.02 |
TERF2 | 1.76 | -1.48 |
c-MYC | -2.75 | -2.25 |
DKC1 | -1.19 | -1.58 |
MRE11A | -1.34 | 1.00 |
RAD50 | -1.85 | -1.68 |
RFC1 | -1.28 | -1.31 |
TNKS1BP1 | 1.33 | -1.82 |
PRPF31 | -1.39 | 1.06 |
PRKCA | 1.40 | -2.23 |
NF-kB family | Â | Â |
NFKBIZ | -1.91 | -2.85 |
NFKBIE | 1.28 | 1.83 |
NFKB2 | 1.26 | -1.33 |
NFKBIB | 1.29 | -1.01 |
IRAK2 | 2.25 | -2.00 |
Tumour necrosis factor | Â | Â |
TNFSF10 | -1.17 | -3.80 |
TNFSF12 | 1.30 | -1.01 |
MAD1L1 | 1.32 | -1.02 |
Transforming growth factor | Â | Â |
TGFB2 | -1.90 | -1.61 |
TGFBRAP1 | 1.39 | 1.18 |
TGFB1 | 1.62 | -1.22 |
TGFBR3 | -2.05 | -2.05 |
SMAD1 | 1.11 | -1.10 |
SMAD2 | -1.06 | -1.10 |
SMAD3 | 1.28 | -1.51 |
SMAD4 | 1.32 | -1.38 |
SMAD5 | 1.04 | -1.34 |
SMAD6 | -1.00 | 1.49 |
SMAD7 | -1.96 | -1.69 |
Mitochondrial function regulators | Â | Â |
PGC-1α | 1.22 | -1.33 |
PGC-1β | 1.04 | -1.25 |