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Figure 6 | Molecular Cancer

Figure 6

From: miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the Oxidative Stress pathway

Figure 6

The miR-193a-3p’s effect on both the in vivo growth and Pa chemoresistance of 5637 and H-bc derived xenografts in nude mice. A, The experimental scheme, 5637 cells or H-bc cells were subcutaneously injected at four points at back of each nude mice, respectively. From the day 4th, PBS, the miR-193a-3p agomiR/antagomiR or the scramble sequence control (Mock) was intratumourly injected into a pair of 5637/H-bc tumors on right back site (NB, the other pair of tumor was injected with the reagents that has nor relevance in this study), respectively, once every two days for 5 times as indicated. From day 6th, each of three mice for 5637 or H-bc received the intraperitoneal injection of PBS or Pa once every two days for 5 times, respectively. B, The image of the representative mice with tumors on the day 25th. C, The mean ± SD of tumor weight of the tumor from same treatment was calculated and plotted, *, p < 0.05, and summarized in table D E, The 5637 or H-bc tumor tissues from each group were fixed on the same slide and immunostained with the indicated antibodies. Levels of Ki67, SRSF2, and LOXL4 proteins in each indicated tumor tissues were scored and summarized.

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