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Figure 7 | Molecular Cancer

Figure 7

From: miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the Oxidative Stress pathway

Figure 7

A Simplified interaction map between the LOXL4 protein with the OS pathway by both protein-protein interaction analysis and literature mining. The red solid lines specify a direct physical interaction between the LOXL4 protein and the indicated proteins. The green arrow lines indicate transcriptional activation by the OS pathway. The green dashed arrow-lines signify the impact on OS pathway via effect on the phosphorylation state, activity or the nuclear-cytoplasmic distribution of Nrf1/2 proteins. T headed purple line indicates the direct interaction of SirT1 with SUV39H1 with a repression effect. The red circles designate the genes that expressed higher in H-bc than 5637 cells, while the blue circles indicate the genes in a reverse state of expression (based on the RNA-seq data, not shown in this paper).

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Molecular Cancer

ISSN: 1476-4598