Table 1 Cell media conditions and corresponding levels of MYC and cell fate in antiestrogen resistant (LCC9) cells
Cell media condition | MYC level; short-term cell fate (72Â h) | MYC level; long-term cell fate (>72Â h) |
|---|---|---|
glucose + glutamine (basal) | High MYC; survival and proliferation; no UPR | High MYC; survival and proliferation; no UPR |
no glucose + no glutamine | Low MYC; apoptosis, ROS/RNS; no UPR | No viable cells |
glucose + no glutamine | High MYC; apoptosis; no UPR | No viable cells |
no glucose + glutamine | High MYC; apoptosis; UPR | Low MYC; survival and slower rate of proliferation |