Figure 4
From: ADAM17 mediates OSCC development in an orthotopic murine model
Bioinformatic analysis of ADAM17-regulated proteome. (A) Clustering of significantly up- and down-regulated proteins in tumor samples compared with control, Student’s t-test, p < 0.05, obtained in Perseus software. (B) Global interaction network by IPA consists of 56 (28%) of 200 differential expressed proteins, up-regulated proteins (red) and down-regulated proteins (green), plus additional interacting molecules that were not identified in this study (white). The two top biological networks generated by IPA were merged to obtain a global view. Major hubs in the network were highlighted in blue.