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Figure 3 | Molecular Cancer

Figure 3

From: MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer

Figure 3

MCRS1 expression promoted tumor metastasis in NSCLC cells. a-c: Assessment of tumor metastasis of EPLC-32 M1 cells with and without MCRS1 silencing in nude mice. (a) Morphological observation of lung and brain metastases. (b) Histopathological observation of representative lung and brain sections, arrow: metastatic cancer cells. (c) The number of metastatic nodules in the lung and brain were counted and analyzed. (d) The relative expressions of MCRS1 mRNA in three groups of 33 tissue sample, including 8 noncancerous tissues, 14 NSCLCs without metastasis, and 11 NSCLCs with metastasis. (e) The expression of MCRS1 and E-cadherin proteins in clinical samples. N: Noncancerous; NM: No metastasis; M: Metastasis. (f) The relationship between the E-cadherin mRNA expression and the status of tumor metastasis. (g) The inverse correlation relationship between the MCRS1 and E-cadherin expression (Pearson’s method, R = -0.438). Luc: cells without MCRS1 silencing; Msh3: cells with stable MCRS1 silencing. Noncancerous: patient with no cancer. No metastasis: patients without any metastases. Metastasis: patients with lymph node metastases and/or blood spread. *P <0.05 (one-way ANOVA and Student’s t-test).

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Molecular Cancer

ISSN: 1476-4598