Figure 1

Example of ploidy analysis by FISH with one GIST (#1C2). A) (Left) for chromosomes 4, 7 and 18, allele frequencies (upper plot) and copy number alteration (bottom plot) are presented. The results of visual genotyping of both parental alleles are indicated as “A” and “B” within the upper plot for each chromosome. B) (Right) representative images of FISH analysis of the same tumor for the same chromosomes. On the upper image, the arrow indicates a cell with two chromosomes 4q and five chromosomes 7q. On the lower image, the arrow indicates a cell with four chromosomes 18 and three chromosome 4 centromeric signals. White bar =10 μm.