Table 1 Summary of mean chromosome number abnormalities in tumors and the % of GISTs harboring the corresponding type of chromosome aberrations
GIST groups | Type of chromosome aberration | Average nb of losses/tumor [min-max] | % of GIST | Average nb of gains/tumor [min-max] | % of GIST | Average nb of cnLOH/tumor [min-max] | % of GIST |
|---|---|---|---|---|---|---|---|
PolyGIST (n = 9) | Whole chr. | 0.44 [0–3] | 22% | 23 [9–43] | 100% | 3.67 [0–12] | 55% |
Chr. Arm | 0 [0] | 0% | 3.11 [1–5] | 100% | 1.11 [0–3] | 55% | |
Segmental | 1.33 [0–10] | 22% | 10 [0–35] | 100% | 2.67 [0–7] | 44% | |
BiGIST (n = 13) | Whole chr. | 2.23 [0–6] | 92% | 0.07 [0–1] | 8% | 0.38 [0–1] | 38% |
Chr. Arm | 1.46 [0–5] | 77% | 0.85 [0–4] | 54% | 0.39 [0–2] | 23% | |
Segmental | 3.23 [0–9] | 69% | 0.77 [0–4] | 38% | 0.85 [0–4] | 31% | |
All GIST (n = 22) | Whole chr. | 1.5 [0–6] | 64% | 9.45 [0–43] | 45% | 1.72 [0–12] | 45% |
Chr. Arm | 0.86 [0–5] | 45% | 1.78 [0–5] | 73% | 0.86 [0–3] | 36% | |
Segmental | 2.45 [0–10] | 50% | 4.54 [0–35] | 64% | 1.59 [0–7] | 36% |