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Figure 2 | Molecular Cancer

Figure 2

From: PDGF receptor alpha inhibition induces apoptosis in glioblastoma cancer stem cells refractory to anti-Notch and anti-EGFR treatment

Figure 2

Differential response of the GBM CSC to GSI-X and AG1478 treatment. (A) GSI-X negatively affect cell proliferation of GBM c-CSC pools after 3 and 5 days of treatment as compared to p-CSC pools by MTS assay. (B) GBM CSC proliferation decrease after 2 days by single EGFR inhibition. Concurrent EGFR and Notch1 inhibition results in a synergistic anti-proliferative effect in c-CSC2 and c-CSC3 pools as compared to relative p-CSC pools. Error bars represent the mean ± SD (n = 3). All data shown are representative of results obtained from experiments conducted three times.

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