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Figure 6 | Molecular Cancer

Figure 6

From: PDGF receptor alpha inhibition induces apoptosis in glioblastoma cancer stem cells refractory to anti-Notch and anti-EGFR treatment

Figure 6

AG1478 and Crenolanib trigger cell growth inhibition in both c-CSC and p-CSC. (A, B) AG1478 alone or in combination with CR determine a significant antiproliferative effect in c-CSC1 and p-CSC1 either at 1 day or 2 days of treatment. No synergistic antiproliferative effect is monitored with the combination therapy. (C, D) AG1478 alone or in combination with CR determine a significant antiproliferative effect in c-CSC2 and p-CSC2 either at 1 day or 2 days of treatment. The combination therapy triggers a synergistic antiproliferative effect in p-CSC2 at day 1. (E, F) AG1478 and CR provided alone determine a significant antiproliferative effect in c-CSC3 and p-CSC3 either at 1 day or 2 days of treatment. The combination therapy triggers a synergistic antiproliferative effect in both c-CSC3 and p-CSC3 at day 1 of treatment. Error bars represent the mean ± SD (n = 3). All data shown are representative of results obtained from experiments conducted twice.

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