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Figure 1 | Molecular Cancer

Figure 1

From: CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to Erlotinib via transcriptional regulation of EGFR

Figure 1

CUL4A is overexpressed and associated with prognosis in lung cancer. (A) RT-PCR analysis of CUL4A mRNA in normal lung tissues (n =22). (B) RT-PCR analysis of CUL4A mRNA in lung cancer tissues (n =22). (C) Relative mRNA levels of CUL4A (normalized to GAPDH) in normal lung tissues and lung cancer tissues were shown as scatter diagram. (D) Immunohistochemistry analysis of CUL4A protein levels in normal lung tissues and NSCLC specimens of different subtypes. (E) CUL4A expression scores in normal lung tissues and lung cancer tissues. (F) Survival curves of NSCLC patients with low versus high expression of CUL4A (n =78; P <0.01, log-rank test). Scale bar indicates 50 μm (D). **P <0.001 vs normal lung tissues based on Student’s t-test. Experiments in A-B were repeated three times. Error bar indicate standard deviation.

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Molecular Cancer

ISSN: 1476-4598