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Figure 5 | Molecular Cancer

Figure 5

From: CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to Erlotinib via transcriptional regulation of EGFR

Figure 5

CUL4A activates the EGFR-mediated signaling pathways. (A) Levels of CUL4A, EGFR, p-EGFR, p-AKT, and AKT were analyzed by Western blot in H1299-pBabe, H1299-CUL4A, H1650-pBabe and H1650-CUL4A cells. (B) Levels of CUL4A, EGFR, p-EGFR, p-AKT, and AKT were analyzed by Western blot in A549-pSuper, A549-shCUL4A, H460-pSuper and H460-shCUL4A cells. (C) Western blot to analyze the effect of erlotinib on the levels of CUL4A, EGFR, p-EGFR, p-AKT, and AKT in H1299-pBabe and H1299-CUL4A cells. (D) MTT analysis of the inhibition of erlotinib on cell proliferation in CUL4A overexprssion cells (H1299-CUL4A and H1650-CUL4A). **P <0.01 vs pBabe cells; ##P <0.01 vs pSuper cells. All results are from three independent experiments. Error bar indicate standard deviation.

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Molecular Cancer

ISSN: 1476-4598