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Figure 6 | Molecular Cancer

Figure 6

From: Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis

Figure 6

Smad4 regulates MMP7 expression in OSCCs. (A) Quantitative RT-PCR expression of the MMP-7 gene in OECM1 and HSC3 cell lines with or without siSmad4. (B) Western blotting revealed the expression levels of MMP7 in OSCC cells with or without siSmad4. (C) MMP7 concentrations and activity in OECM1 and HSC3 media were assessed by ELISA and casein zymography, respectively. Cell culture media were collected and concentrated from Smad4 silencing OSCC cell lines. Each data point represents the mean ± SD of at least three independent experiments. The asterisk indicates as statistically the significant difference (*, p <0.05) compared to control.

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Molecular Cancer

ISSN: 1476-4598