Figure 5
From: OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer
Overexpression of OTUB1 promotes CRC liver metastasis in vivo. SW480-OTUB1 or SW480-Control cells were injected into the spleens of nude mice. Ten weeks later, the mice were sacrificed. (A) Representative images of general livers after tumor cell injection into the spleen. The metastatic nodules are indicated with red arrows. (B) Representative results for HE and IHC staining of metastatic nodules in the livers are shown. The metastatic nodules are indicated with red arrows. The scale bar represents 50 μm. The statistical analyses are shown in (C) (n = 8; **P <0.01).