OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer

Table 2 Multivariate analysis for PFS and OS

Variable	PFS		OS
	HR (95% CI)	p value	HR (95% CI)	p value
Age (year,<65 vs ≥65)	1.29 (0.81-2.07)	0. 284	1.31 (0.82-2.10)	0.256
Gender (male vs female)	0.77 (0.48-1.22)	0.269	0.82 (0.50-1.27)	0.340
Tumor location (colon vs rectum)	1.39 (0.88-2.07)	0.161	1.36 (0.86-2.15)	0.184
Tumor size (cm, <5 vs ≥5)	0.83 (0.48-1.43)	0.498	0.85 (0.49-1.47)	0.553
Tumor invasive depth (T1-2 vs T3-4)	0.82 (0.33-2.00)	0.658	0.77 (0.31-1.90)	0.567
Lymph node status (<1 vs ≥1)	2.35 (1.25-4.41)	0.008*	2.43 (1.30-4.59)	0.006*
Distant metastasis (No vs Yes)	7.89 (4.58-13.61)	<0.001*	9.41 (5.49-16.16)	<0.001*
Preoperative CAE (ng/mL, <5 vs ≥5)	1.45 (0.86-2.44)	0.160	1.54 (0.92-2.56)	0.101
Chemotherapy (Yes vs no)	1.55 (0.94-2.56)	0.087	1.59 (0.96-2.62)	0.069
OTUB1 (low vs high)	1.61 (1.01-2.59)	0.049*	1.77 (1.10-2.86)	0.019*

PFS progression-free survival, OS overall survival, HR hazard ratio, CI Confidence interval.
*Statistically significant P <0.05.

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