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Figure 2 | Molecular Cancer

Figure 2

From: Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation

Figure 2

Expression patterns of DNMT1 in BRCA1-mutated and non-mutated breast cancer. A and C, relative DNMT1 mRNA levels were measured in non-mutated and BRCA1-mutated breast cancer, and their adjacent normal breast tissues. Bi and Di, sections were subjected to immunostaining for DNMT1 in non-mutated and BRCA1-mutated breast cancer, and their adjacent normal breast tissues. Arrow shows positive staining for DNMT1 in the nuclei. Bii and Dii, summary of the percentages of DNMT1-positive cells from the measurements shown in Bi and Di, respectively. Magnification is 400×. Ei and Eii, correlation between the DNMT1-positive cells and methylated sites (+182) or (-99 to +521) in BRCA1-mutated breast cancer and adjacent normal breast tissues. Eiii and Eiv, correlation between the relative DNMT1 mRNA levels and methylated sites (+182) or (-99 to +521) in BRCA1-mutated breast cancer and adjacent normal breast tissues. Open circles, normal breast tissues; closed circles, breast cancer tissues (each group n = 15).

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