Skip to main content
Figure 3 | Molecular Cancer

Figure 3

From: Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer

Figure 3

Vinculin regulates CRC metastasis via β-catenin. (A) Immunofluorescence analysis of β-catenin (green) in SW480 cells infected with vinculin or control siRNA. Merged images represent overlays of β-catenin (green) and nuclear staining by DAPI (red). (B) Immunofluorescence analysis of β-catenin (green) in SW620 cells infected with the vinculin or control vector. (C) Transwell migration and invasion assays for SW480 cells infected with control or vinculin siRNA along with lentiviral vector expressing β-catenin siRNA. Representative images are shown on the left, and the quantification of 10 randomly selected fields is shown on the right. (D) Transwell migration and invasion assays using SW620 cells infected with control or vinculin vectors along with lentiviral vector expressing β-catenin.

Back to article page

Molecular Cancer

ISSN: 1476-4598