Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer

Table 1 Correlations of Clinico-pathological variables with vinculin and β-catenin expression

	Vinculin		P value	Membrane-bound β-catenin		P value
	Low	High		Absent	Present
Total cases	145	83		138	90
Gender
Male	76	49	0.4068	71	54	0.2048
Female	69	34		67	36
Age
<60	55	37	0.3304	61	31	0.1677
>60	90	46		77	59
Differentiation
Well	59	51	0.0021*	56	54	0.0163*
Morderate	62	17		55	24
Poor	24	15		27	12
Depth of Tumor
T1-T2	47	32	0.3866	39	40	0.0121*
T3-T4	98	51		99	50
Tumor stage
I - II	82	51	0.4885	76	57	0.2716
III - IV	63	32		62	33
Location
Signoid	38	24	0.7572	40	22	0.5428
Colon /Rectum	107	59		98	68
Vascular invasion
Negative	77	56	0.0371*	85	48	0.2203
Positive	68	27		53	42
Node Metastasis
Negative	72	54	0.0273*	65	61	0.0027*
Positive	73	29		73	29
Organ metastasis
Negative	115	77	0.0078*	110	89	0.0159*
Positive	30	6		28	8

ISSN: 1476-4598