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Table 2 Univariate and multivariate analysis for overall survival (Cox proportional hazards regression model)

From: Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer

Factors

Univariate analysis

Multivariate analysis1

 

HR

95%CI

P

HR

95%CI

P

Gender (male/female)

1.148

0.825-1.596

0.412

-

-

-

Differentiation (well/ moderately, poorly)

1.340

0.966-1.860

0.080

-

-

-

Vascular invasion (absent/present)

1.843

1.327-2.561

0.0002*

1.410

0.996-1.997

0.0527

Depth of Tumor (T1-T2/T3-T4)

1.185

0.850-1.453

0.317

-

-

-

Node Metastasis (absent/present)

2.739

1.963-3.820

0.0015*

1.631

1.139-2.315

0.0062*

Organ metastasis (absent/present)

4.509

2.915-6.975

<0.0001*

5.401

3.379-8.634

<0.0001*

Vinculin expression (high/low)

1.805

1.262-2.582

0.0012*

2.048

1.401-2.995

0.0002*

membrane-bound β-catenin expression (absent/present)

2.420

1.685-3.475

<0.0001*

2.024

1.402-2.923

0.0019*

  1. 1Multivariate analysis performed only for variables significant in the univariate analysis.
  2. *P < 0.05.
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Molecular Cancer

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