Skip to main content

Table 1 Effects of co-treatment of breast cancer cell lines with probenecid and bisphosphonates on the expression of KLF2

From: Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells

KLF2 expression

MCF-7

T47D

MDA-MB-231

ZA 20 μM

13.0** (2.3-60.8)

3.0* (1.2-7.6)

3.1 (0.6-16.0)

ZA + Prob

32.4** (5.8-198.5)

2.6* (1.0-6.7)

5.1* (0.7-25.6)

RIS 50 μM

1.6 (0.3-10.1)

2.1* (1.0-3.7)

3.5* (0.6-18.8)

RIS + Prob

4.2 (0.7-35.9)

1.7 (0.7-4.7)

3.4 (0.5-19.2)

IBN 50 μM

2.4 (0.5-15.2)

2.2* (0.9-4.9)

2.4 (0.3-17.3)

IBN + Prob

6.1* (0.8-31.7)

2.2* (0.9-5.9)

4.8** (0.7-28.4)

ALN 50 μM

5.8* (1.2-33.4)

2.0 (0.8-5.5)

1.4 (0.2-11.4)

ALN + Prob

36.1** (9.7-141.4)

1.8 (0.8-5.6)

3.2 (0.4-31.1)

Prob

1.0 (0.3-5.0)

1.0 (0.8-1.3)

1.3 (0.1-9.4)

  1. The expression ratios of KLF2, in MCF-7, T47D and MDA-MB-231 breast cancer cells after treatment with ZA (zoledronic acid), RIS (risedronate), IBN (ibandronate), ALN (alendronate) alone and in combination with probenecid (Prob) compared to untreated controls and normalized to 36B4 (acidic ribosomal phosphoprotein P0) are shown. (**p < 0.001, *p < 0.01 calculated with REST [38]).