Figure 3
From: RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes
MLL-AF9 knockdown associated enriched functional gene annotations identified via DAVID. Enriched annotation terms (fold enrichment (FE) ≥ 1.5 and p < 0.1) were manually assorted to six higher-order terms according to the major role of the process in the biological setting under investigation. Annotation terms assigned to two higher-order terms are indicated by dotted division lines between these two. Annotation terms which could not be assigned to one of the five specific higher-order terms are depicted under the term “other”. Some annotations were abbreviated as indicated by superscript numbers: 1Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, 2Regulation of transcription from RNA polymerase II promoter. Columns show proportion of down- (white) and up-regulated (black) genes after MLL-AF9 knockdown in THP1 cells. All differentially expressed genes contained in each functional annotation term are given in Additional file 4 together with the term identifier, FE and p value of the terms.