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Figure 2 | Molecular Cancer

Figure 2

From: Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

Figure 2

Hypoxically induced microRNAs are transcriptionally regulated by HIF. microRNAs within 50 kb of a HIF-binding site were analysed by GSEA using the pan-genomic microRNA datasets of fold change in expression at (A) 16 hours, (B) 32 hours and (C) 48 hours. (D) Heat map showing fold change after differing periods of hypoxia for all HIF-binding microRNAs. (E & F) RNA-seq and ChIP-seq tracks showing HIF binding and transcriptional up-regulation of previously un-annotated transcripts hosting the loci MIR27A and MIR30D. Red tracks show strand-specific ribo- RNA-seq in normoxia and hypoxia. RNA-seq reads are split between ones mapping in the plus and minus strand under normoxia or hypoxia. Purple tracks show ChIP-seq using antibodies against the indicated HIF subunit.

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Molecular Cancer

ISSN: 1476-4598